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Estrogen-related receptor alpha
Estrogen-related receptor alpha (ERR-α), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is encoded by the ''ESRRA'' (Estrogen Related Receptor Alpha) gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2101 )〕 ERR-α was originally cloned by DNA sequence homology to the estrogen receptor alpha (ER-α, NR3A1),〔 but subsequent ligand binding and reporter-gene transfection experiments demonstrated that estrogens did not regulate ERR-α. Currently, ERRα is considered an orphan nuclear receptor.〔〔
==Tissue distribution==
ERR-α has wide tissue distribution but it is most highly expressed in tissues that preferentially use fatty acids as energy sources such as kidney, heart, cerebellum, intestine, and skeletal muscle.
Recently, ERR-α has been detected in normal adrenal cortex tissues, in which its expression is possibly related to adrenal development, with a possible role in fetal adrenal function, in DHEAS production in adrenarche, and also in steroid production of post-adrenarche/adult life.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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